Several neurodegenerative diseases, including glaucoma, diabetic retinopathy, and age-related macular degeneration all involve retinal cell death. Neuroprotection is an important goal for the prevention and treatment of neurodegeneration. To this end, having reliable experimental [....] » Read More
Ocular injuries are kind of common ocular disorders sndvtheur timely treatment is very important to prevent any kind of visual loss the type of ocular injuries are: Perforating, Non perforating, Blunt, Finger nail injuries, Chemical, R t a related eye injuries, Sports related, H [....] » Read More
Leber hereditary optic neuropathy (LHON) is a rare, maternally inherited mitochondrial genetic disease with a high unmet medical need. Three primary point mutations in the mtDNA are responsible for LHON in 90% of subjects: G3460A, G11778A and T14484C, located respectively in the [....] » Read More
Purpose: To assess the diagnostic usefulness of retinal nonperfusion to classify eyes based on diabetic retinopathy (DR) severity on OCT angiography (OCTA) and determine whether wider field of view (FOV) OCTA protocols enhance the diagnostic usefulness of retinal nonperfusio [....] » Read More
Background: In this GP surgery in the past, patients were seen by both a GP doctor and optician prior to an ophthalmology referral. Due to the increased workload, referrals were then sent based purely on optician advice. The project was carried out to assess whether this pathway [....] » Read More
Leber’s hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progres- sive retinal ganglion cell dysfunction usually in the absence of extra-ophthalmic symptoms. There are no long-term neuroprotective agents for LHON. Oral nicoti [....] » Read More
Introduction: This study compared the outcomes of the Preserflo microshunt to trabeculectomy in patients diagnosed with primary open-angle glaucoma (POAG). The primary outcomes analyzed were post-operative intraocular pressure (IOP) and the medication burden following each surgic [....] » Read More
Introduction: Vogt-Koyanagi-Harada (VKH) disease is rarely observed in preschool-aged children, and when it does occur, it typically presents with exudative retinal detachment during the acute phase. Treatment in this population commonly involves corticosteroids, immunosuppressan [....] » Read More
Purpose: To investigate the differences in the effects of phacoemulsification, viscosynechiolysis, and Trabeculectomy on cases with a recent history of Acute Primary Angle Closure (APAC). Methods: Patients with cataracts, Peripheral Anterior Synechia (PAS), and a history of APAC [....] » Read More
Purpose: Herein, we compared the efficacy among the Ocular Trauma Score (OTS), Toddlers Ocular Trauma Score (TOTS), and Pediatric Ocular Trauma Score (POTS) for prognosis prediction in Indian children who had mechanical ocular conditions causing traumatic cataract. Methods: This [....] » Read More
Introduction: Goldenhar Syndrome (Oculo-Auriculo-Vertebral Dysplasia, OAVS) Is A Rare, Congenital Disease Arising From The Abnormal Development Of The First And Second Branchial Arches. The Incidence Is Between 1:3500 And 1:5600, With A Male: Female Ratio Of 3:2. Method: We Retr [....] » Read More
Introduction: History has shown that restricted use of oxygen leads to higher mortality and neuro disability, whereas liberal usage is linked to ROP. With the upgradation of Neonatal intensive care unit (NICU) of a tertiary health care unit, the number of premature infants [....] » Read More
Background: We aimed to present the outcomes and complications following phacoemulsification cataract surgery complicated by anterior capsule tears. Methods: This study prospectively included patients who had phacoemulsification cataract surgery with anterior capsule tears. The [....] » Read More
Background: Pan-retinal laser photocoagulation (PRP) is used in the management of diabetic retinopathy, aimed at preventing the growth of abnormal blood vessels in the retina and reducing the risk of vision loss. Absorption of laser occurs from pigment cells within the retina, wh [....] » Read More
Purpose: Demographic representation in Diabetic Retinopathy Clinical Research (DRCR) studies is understudied and impacts the generalizability of results. This research aims to determine if the DRCR demographic data is representative of the United States (US) general diabetic popu [....] » Read More
Purpose: Large language models (LLMs) can accept text and image prompts as multimodal input. With implications for ophthalmology as a field, we evaluated the performance of several LLMs on relevant clinical vignette questions. Methods: We collected 100 cases of JAMA Ophthalmolog [....] » Read More
Purpose: To evaluate the use of a novel software application downloadable on commercially available virtual reality (VR) headset in measuring ocular tropia. Methods: This study included 20 patients with ocular tropia. A masked ophthalmologist quantified the tropia using near and [....] » Read More
Vibrational Optical Coherence Tomography (VOCT) is a new non-invasive technique that provides an image based upon infrared light reflections from ocular components and simultaneous analysis of acoustic sound vibrations. The technology provides information to study the structure a [....] » Read More
Purpose: To review consecutive cases of dislocated in the bag IOLs managed by the belt loop scleral fixation technique. Methods: Retrospective review of 71 consecutive cases managed using the belt loop scleral fixation scleral fixation technique. Results: 71 consecutive cases [....] » Read More
Two autopsy studies of optic nerves from 76 eyes of abusive head trauma (AHT) suspects demonstrated block of orthograde axonal transport in the lamina cribrosa (LC) in 94% of cases by APP-A4 immunohistochemistry (IHC).1,2 APP-A4 is the only currently available IHC marker f [....] » Read More
We use mice to determine molecular mechanisms that contribute to intraocular pressure (IOP) elevation and glaucoma. Glaucoma is a common neurodegenerative disease that kills retinal ganglion cells. Elevated IOP is an important, causative risk factor for developing glaucoma. I wil [....] » Read More
We invented a novel resistance sensing mechanical principle which enables precise injection of flowable material into the superachoroidal space. Based on this principle, after three generations of iterative enhancements, the latest device has been optimized to administer wi [....] » Read More
Purposes: To investigate the role of wide-field en face imaging of retinal pigment epithelium (RPE) alterations in rapid classification of central serous chorioretinopathy (CSCR) using swept-source optical coherence tomography (SS-OCT), in accordance with the latest novel classif [....] » Read More
Purpose: To evaluate the findings of optical coherence tomography angiography (OCTA) vessel density parameters in patients with primary open-angle glaucoma (POAG) and investigate both diagnostic performance of OCTA and correlations between control group and patients at diffe [....] » Read More
Background: Laser photocoagulation and/or intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections constitute the current standard treatment for retinopathy of prematurity (ROP). This systematic review and meta-analysis aimed to assess the efficacy and safety o [....] » Read More
Purpose: The purpose of this study is to compare the incidence and characteristics of ocular trauma in children presenting during pandemic to those in pre-pandemic era. Method: In this study, we retrospectively reviewed the charts of all children with ocular injuries prese [....] » Read More
Purpose: To educate beginner surgeons on dos and don'ts of performing lensectomy in microspherophakic subluxated lenses in children Setting/Venue: Pediatric Ophthalmology and Strabismus Department, Al-Shifa Trust Eye Hospital, Rawalpindi Method: A 2-year-old child with [....] » Read More
Background: Pterygium is a common ocular surface disease. Recurrence is the greatest concern in the treatment of pterygium. Thus, a standardized and effective treatment modality with minimal risk for complications is needed for the management of pterygium. The aim of this systema [....] » Read More
Background: Intravitreal injection (IVI) therapy used in the management of exudative retinal diseases has expanded significantly following the introduction of anti-vascular endothelial growth factor (anti-VEGF) drugs. With an ageing population in the UK, the numbers of patients r [....] » Read More
Background: Cataract surgery is the most commonly performed elective surgery in the UK with more than 400,000 operations done each year. They aim to improve vision by restoring a clear intraocular lens. Patients with smaller eyes have a higher risk of intra- and post-op comp [....] » Read More
Recent developments in artificial intelligence (AI), in particular machine learning (ML) and Deep Learning (DL), have demonstrated promising outcomes in various fields, including the internet of things, automated machinery, and healthcare. DL techniques are dominating medical ima [....] » Read More
Purpose: To investigate the relationship of retinal structure as measured on optical coherence tomography (OCT), to retinal function as assessed by electrophysiology, consisting of pattern (pERG) and full-field electroretinogram (ffERG), in patients with Immune-mediated Reti [....] » Read More
Background: Diabetic Retinopathy (DR) is a severe complication of diabetes that affects retinal blood vessels and can lead to blindness. The Middle East faces a significant public health challenge due to the high prevalence of DR among diabetics, with rates reaching up to 64% in [....] » Read More
Over the past two decades, surgical options for intraocular lens (IOL) implantation in the absence of capsular support have evolved. Surgical indications for secondary IOL implantation are mainly due to complicated cataract surgery, trauma, or inherited conditions such as Marfan [....] » Read More
Background: Thermal pulsation system is a new used therapy that uses heat and massage to treat dry eye disease; thus, some trials have been published to compare it with the conventional treatment. The aim of this study is to conduct a systematic review and meta-analysis comp [....] » Read More
Purpose: Aim is to give an overview of different lensectomy techniques which can be utilized in various scenarios of subluxated lenses in children. Method: We present various lensectomy techniques with or without intraocular lens implantation in five pediatric [....] » Read More
Stickler Syndrome is an uncommon frequently undiagnosed multisystem collagenopathy with significant genetic and phenotypic heterogeneity, a condition that carries a risk for significant ocular complications, ranging from severe myopia to retinal detachment and vision loss. System [....] » Read More
The increasing workload placed on the glaucoma service in Ireland has led to the implementation of a virtual glaucoma service in the country’s leading eye hospital. Briefly, those with stable glaucoma who require monitoring attend on a regular basis for visual acuity, IOP m [....] » Read More
Introduction: In this review, an analysis of the outcomes of Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) was done in patients with Primary Open-Angle Glaucoma (POAG), with outcomes in one study being compared to trabeculectomy. Trabeculectomy is already accepted as an e [....] » Read More
Purpose: While AI chatbots are increasingly used for patient education, their effectiveness in providing accurate, comprehensive, and understandable information about ophthalmologic conditions remains understudied. We performed an observational, cross-sectional study to eval [....] » Read More
Introduction: Rhabdomyosarcoma is a rare paediatric cancer, with the head and neck region representing a major anatomical site for rhabdomyosarcoma. In particular, orbital rhabdomyosarcoma is the most common region among children. However, rhabdomyosarcoma originating from the co [....] » Read More
We describe the first reported case of granulomatosis polyangiitis (GPA)-associated sclerokeratitis in a patient with treated ocular adnexal lymphoma (OAL). The patient presented with pain and decreased vision in the left eye over several weeks. Past medical history was significa [....] » Read More
Purpose: Acute acquired comitant esotropia (AACE) is a rare form of strabismus presenting as a sudden onset, large angle, esotropia in older children and young adults. Of the 3 subtypes, Type 3 is historically associated with myopia and a period of excessive convergence rela [....] » Read More
Infectious keratitis (IK) is the fifth leading cause of blindness globally. Gold-standard diagnostic techniques of microscopy, cultures and sensitivity from corneal scrapes are limited by low sensitivity, invasiveness, and time lag for identifying causative organisms. This revie [....] » Read More
Title : Submacular haemorrhage due to wet age-related macular degeneration: What to do?
Tim Jackson, King’s College London, United Kingdom
Aim: To consider the presentation, management options, and randomised controlled trials investigating submacular haemorrhage (SMH) secondary to neovascular age-related macular degeneration (AMD), with a focus on the use of tissue plasminogen activator (TPA) and pneumatic dis [....] » Read More
Title : Monovision cataract surgery made simple
Shadrokh Nabili, University Hospitals of Morecambe Bay NHS Foundation Trust, United Kingdom
Background: The demand for presbyopia-correcting IOLs (intraocular lenses) at the time of cataract surgery is increasing. An alternative to implanting these lenses is monovision cataract surgery. Although it has limitations, it may be offered to patients as an option. This i [....] » Read More
Title : Mast cells in infllammation: Role of cytokines
Pio Conti, University of Chieti, Italy
Mast cells (MCs) originate from CD34+/CD117+/CD13+ pluripotent hematopoietic stem cells and they express the c-Kit receptor (c-Kit-R) which regulates their proliferation and sustains their survival, differentiation, and maturation. MCs are immune tissue cells derived from bone ma [....] » Read More
Title : Why was Leonhard Euler blind?
John David Bullock, Wright State University, United States
Leonhard Euler was one of the most eminent mathematicians of all time. In 1735, he developed right periocular swelling, partial loss of vision, and the onset of lifelong recurrent fevers from a heretofore-unknown affliction. Three years later, he developed an infection in the rig [....] » Read More
Title : Results of a photobiomodulation treatment in patients with macular degeneration age-related (ADM) with a new low-fluence, multifrequency wearable device: Positive medium-term effects (6 months) of visual function
Pierdomenico D Andrea, University “G. D’Annun, Italy
Introduction: In our previous study, we demonstrated the efficacy and short-term safety of low-fluence photobiomodulation (LF-PBM) for atrophic macular degeneration (AMD) using a newly developed wearable multifrequency device. In this study, we report the six-month follow-up resu [....] » Read More
Title : Visual snow syndrome: Unraveling a mysterious visual disorder
Oliwia Kamieniecka, Medical Univeristy of Warsaw, Poland
Visual Snow Syndrome (VSS) is a neurological disorder characterized by persistent visual disturbances, most notably a continuous “visual snow” or static across the visual field, which can profoundly impact quality of life. In addition to the primary symptom of visual [....] » Read More
Title : GB10, a best-in-class antibody fusion protein targeting VEGF/Ang-2, exhibits promising therapeutic efficacy for neovascular eye diseases
Suofu Qin, Kexing Biopharm Co., Ltd., China
In clinical practice, anti-vascular endothelial growth factor (VEGF) therapies have been successfully applied to patients with neovascular eye diseases. However, unmet clinical needs have not yet been fully addressed, as about 20% of patients do not response to anti-VEGF mo [....] » Read More
Title : Roth spots serving as a clue to underlying acute myeloid leukemia
P Muralidhar, AIIMS Mangalagiri, India
Acute myeloid leukemia is one of the causes of Roth spots. We report here a female patient in her early thirties, of Asian origin, presenting to our ophthalmology outpatient clinic with complaints of decreased visual acuity in the Right eye along with generalized weakness, palpit [....] » Read More
Title : The effectiveness of surgical treatment of terson syndrome
Anna Rusanovskaia, State Budgetary Healthcare Institution, Russian Federation
Terson's syndrome (hemorrhagic oculocerebral syndrome) is a vitreal, preretinal, subgialoid or subretinal hemorrhage associated with acute subarachnoid, intracerebral hemorrhage, or traumatic brain injury. The clinical picture is characterized by a sharp mono or bilateral los [....] » Read More
Title : Optimization of the ocular surface using Intense Pulsed Light (IPL) therapy before cataract surgery
Dmytro Zhaboiedov, Bogomolets National Medical University, Ukraine
Introduction: Dry eye disease (DED) is a prevalent condition among patients undergoing cataract surgery, significantly impacting preoperative measurements and postoperative recovery. One of the primary contributors to DED is meibomian gland dysfunction (MGD), which leads to tear [....] » Read More
Title : Surgical treatment of chronic macular hole by hydraulic mobilization of the central parts of the retina
Anna Rusanovskaia, State Budgetary Healthcare Institution, Russian Federation
Objective: to evaluate the safety and effectiveness of the technique of hydraulic mobilization of the central parts of the retina in the surgical treatment of chronic macular ruptures. Materials and methods: 11 patients (11 eyes) with chronic macular rupture were under obse [....] » Read More
Title : Daily artificial tears as a preventive measure for dry eye syndrome in medical students: A systematic review and meta-analysis
Nodira Makhmudova, Akfa Medline University Hospital, Uzbekistan
Purpose: To determine the efficacy of the daily artificial tears usage as a dry eye syndrome prophylaxis among medical students, who are at increased risk due to lifestyle factors. Methods: We performed a systematic review and meta-analysis following the Preferred Reporting Item [....] » Read More
Title : Atopy and its role in the development and progression of keratoconus: A systematic review and meta-analysis
Mokhiryam Aliyeva, Akfa Medline University Hospital, Uzbekistan
Purpose:Progressive condition which is characterized by corneal thinning,distorted astigmatism and impaired vision is called keratoconus (KC). Development of a disease is often associated with genetic predisposition and environmental factors. This study seeks to investigate the r [....] » Read More
Title : Anti-inflammatory properties of omega-3 fatty acids and its clinical significance in the treatment of dry eye syndrome
Jamshid Mamatov, Akfa Medline University Hospital, Uzbekistan
Purpose: to evaluate the effectiveness of nutritional omega-3 fatty acid supplementation in the management of dry eye disease (DED). We focused on the anti-inflammatory properties of omega-3 and its impact on the symptoms and signs of DED, especially in patients with meibom [....] » Read More
Title : Effect of combination of anti-VEGF and corticosteroid use in two patients with early-onset central retinal vein occlusion
Javokhirbek Ravshanbekov, Akfa Medline University Hospital, Uzbekistan
Purpose: Central Retinal Vein Occlusion (CRVO) is an uncommon condition in young adults that can lead to severe visual impairment if untreated. This study evaluates the treatment outcomes of two young male patients with CRVO who underwent a combination of intravitreal anti-V [....] » Read More
Title : Overnight orthokeratology combined with atropine 0.01% in Chinese pre-adolescent myopes
Kang Zhao, XiuZhou Medical University, China
Backgroud: Orthokeratology has been proved to temporarily alter the equivalent sphere. On condition that orthokeratology combined with atropine 0.01% +brinzolamide tarding myopia deserves attention. Purpose: A comparative study was performed to evaluate the effectivene [....] » Read More
Title : Case report of lyme disease associated proliferative vitreoretinopathy, challenges in diagnostic and treatment
Lesia Parkhomchuk, Center of Clinical Ophthalmology, Ukraine
A woman 30 y. with complains of gradual bilateral visual loss and headache during 6 months. Vis OD=0.25, Vis OS=0.04. Anterior eye segment without changes, IOP normal. On the eye fundus – massive proliferative changes and partial hemophthalmia. Serology negative for Tubercu [....] » Read More
Title : Hyperbaric oxygen therapy for crao in a pediatric patient: A case of sudden unilateral visual loss Post-DSA of an arteriovenous malformation
Carmen N Plaza Mejias, UPR-SOM, Puerto Rico
Central retinal artery occlusion (CRAO) is an ophthalmic emergency that typically presents as a sudden, profound, and painless monocular visual loss, potentially leading to permanent blindness. While rare in the pediatric population, the etiology in children can differ from that [....] » Read More
Title : Protein and mineral malnutrition in military personnel and its association with dry eye syndrome
Jamshid Mamatov, Akfa Medline University Hospital, Uzbekistan
Military personnel are frequently faced with environmental challenges and operational demands.These barriers increase vulnerability to nutrient deficiencies including minerals and proteins imbalance. Such nutrient deprivation can make a disadvantageous impact on ocular wellness,e [....] » Read More
Title : Inhibitory effects of novel artemisinin derivative on laser-induced choroidal neovascularization via regulating AKT and ERK1/2 pathways
Yandong Wang, Sun Yat-sen University, China
Choroidal neovascularization (CNV) is a major cause of blindness in ocular fundus disease. The major defects of the current first-line anti-VEGF drugs for fundus disease are the high administration frequency and ocular complications. Meanwhile?about 40% of fundus disease patients [....] » Read More