Minckler Don S, UCI Gavin Herbert Eye Institute, United States
Two autopsy studies of optic nerves from 76 eyes of abusive head trauma (AHT) suspects demonstrated block of orthograde axonal transport in the lamina cribrosa (LC) in 94% of cases by APP-A4 immunohistochemistry (IHC).1,2 APP-A4 is the only currently available IHC marker f [....] » Read More
Title : Eyes and guts connection: Microbiomes and their role in ocular health
Edward Charles Kondrot, Healing the Eye Wellness Center, United States
The human microbiome, particularly the gut microbiota, has been increasingly recognized for its profound impact on overall health, including ocular health. This abstract explores the intricate relationship between the gut microbiome and the eye, highlighting emerging research tha [....] » Read More
Title : Why was Leonhard Euler blind?
John David Bullock, Wright State University, United States
Leonhard Euler was one of the most eminent mathematicians of all time. In 1735, he developed right periocular swelling, partial loss of vision, and the onset of lifelong recurrent fevers from a heretofore-unknown affliction. Three years later, he developed an infection in the rig [....] » Read More
Title : Developing resilience-based treatments for glaucoma
Simon John, Columbia University, United States
We use mice to determine molecular mechanisms that contribute to intraocular pressure (IOP) elevation and glaucoma. Glaucoma is a common neurodegenerative disease that kills retinal ganglion cells. Elevated IOP is an important, causative risk factor for developing glaucoma. I wil [....] » Read More
Title : A factorial randomized controlled trial of tissue plasminogen activator and/or perfluoropropane for the treatment of submacular hemorrhage secondary to neovascular age-related macular degeneration (TAPAS)
Tim Jackson, King’s College London, United Kingdom
Aim: To consider the presentation, management options, and randomised controlled trials investigating submacular haemorrhage (SMH) secondary to neovascular age-related macular degeneration (AMD), with a focus on the use of tissue plasminogen activator (TPA) and pneumatic dis [....] » Read More
Title : Monovision cataract surgery made simple
Shadrokh Nabili, University Hospitals of Morecambe Bay NHS Foundation Trust, United Kingdom
Background: The demand for presbyopia-correcting IOLs (intraocular lenses) at the time of cataract surgery is increasing. An alternative to implanting these lenses is monovision cataract surgery. Although it has limitations, it may be offered to patients as an option. This i [....] » Read More
Title : An innovative in vitro human-based millifluidic platform as useful tool to underlying mechanisms of neurodegeneration in glaucoma
Anna Maria Bassi, University of Genoa, Italy
Several neurodegenerative diseases, including glaucoma, diabetic retinopathy, and age-related macular degeneration all involve retinal cell death. Neuroprotection is an important goal for the prevention and treatment of neurodegeneration. To this end, having reliable experimental [....] » Read More
Title : Visual snow syndrome: Unraveling a mysterious visual disorder
Oliwia Kamieniecka, Medical Univeristy of Warsaw, Poland
Visual Snow Syndrome (VSS) is a neurological disorder characterized by persistent visual disturbances, most notably a continuous “visual snow” or static across the visual field, which can profoundly impact quality of life. In addition to the primary symptom of visual [....] » Read More
Title : The glaucoma drainage device (GDD) experience in a tertiary referral centre in Ireland over the past six and a half years
Liam Bourke, Irish College of Ophthalmology, Ireland
Background: The control of intraocular pressure (IOP) is a cornerstone of treatment for glaucoma. Glaucoma drainage devices (GDDs) are increasingly used in cases with uncontrolled IOP, despite maximum medical therapy. Recent trials demonstrated that the Baerveldt implant ach [....] » Read More
Title : Fresh human myopic lenticule intrastromal implantation for keratoconus using smile surgery in a long-term follow-up study: Ultrastructural analysis by transmission electron microscopy
Faruk Semiz, Eye Hospital, Albania
Purpose: To investigate new intrastromal histological structures that develop after myopic human lenticular implantation in keratoconus with femtosecond laser–assisted small incision lenticule extraction (SMILE) surgery using transmission electron microscopy. Methods: Sixt [....] » Read More
Title : Clinical characteristics of retinal detachment associated with atopic dermatitis
Hyoung Seok Kim, Kim's Eye Hospital, Korea, Republic of
Purpose: To evaluate the clinical characteristics and surgical outcomes of retinal detachment associated with atopic dermatitis. Methods: A retrospective investigation of clinical notes of 37 patients with retinal detachment associated with atopic dermatitis was conducted from J [....] » Read More
Title : GB10, a best-in-class antibody fusion protein targeting VEGF/Ang-2, exhibits promising therapeutic efficacy for neovascular eye diseases
Suofu Qin, Kexing Biopharm Co., Ltd., China
In clinical practice, anti-vascular endothelial growth factor (VEGF) therapies have been successfully applied to patients with neovascular eye diseases. However, unmet clinical needs have not yet been fully addressed, as about 20% of patients do not response to anti-VEGF mo [....] » Read More
Title : Early retinal microcirculation loss in non-functioning pituitary adenomas before visual field defect by WF SS-OCTA
Chong Tang, The First Affiliated Hospital of Chongqing Medical University, China
Purpose: To evaluate the early retinal microcirculation alteration in non-functioning pituitary adenomas (NFPA) before visual field defects (VFD) by wide-field swept-source optical coherence tomography (WF SS-OCTA) Methods: 82 NFPA patients without VFD and 82 age-matched, s [....] » Read More
Title : Enhancing patient experience: A study of modified manual irrigation ICL implantation vs. smile
Khan Muhammad Ahmad, Aier Eye Hospital Group, China
This study aims to assess the intraoperative experiences of patients undergoing a modified manual irrigation implantable collamer lens (MI-ICL) implantation technique in comparison to femtosecond laser small incision lenticule extraction (SMILE). A customized questionnaire, devel [....] » Read More
Title : Effect of Nd: YAG capsulotomy on retina
Chong Tang, The First Affiliated Hospital of Chongqing Medical University, China
Purpose: To evaluate the effect of neodymium: yttrium aluminium garnet (Nd: YAG) laser capsulotomy on retinal thickness and microcirculation by wide-field swept-source optical coherence tomography (WF SS-OCTA). Methods: 62 eyes of 62 patients who had posterior capsule opacificat [....] » Read More
Title : Comparative evaluation of single-incision ICL implantation with and without ophthalmic viscosurgical devices: Implications for postoperative IOP and visual outcomes
Khan Muhammad Ahmad, Aier Eye Hospital Group, China
Objective: To evaluate the efficacy and safety of a single-incision intraocular lens (ICL) implantation technique with and without use of ophthalmic viscosurgical devices (OVDs), focusing on postoperative intraocular pressure (IOP) changes and visual outcomes. Methods: This stud [....] » Read More
Title : Colour doppler imaging of ocular circulation in diabetic patients with and without diabetic retinopathy
Aakriti Agarwal, Hamdard Institute of Higher Education and Research, India
Diabetic Retinopathy (DR) is the most common microvascular complication in Diabetic patients and the leading global cause of vision loss in working middle-aged adults. Exposure to hyperglycaemia over an extended period and duration of diabetes are the most common risk f [....] » Read More
Title : Understanding the basics of DSAEK
Sarita Agarwal, Santosh Medical College and Hospital, India
Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) is a posterior lamellar keratoplasty technique that specifically targets corneal endothelial dysfunction. It involves replacing the recipient's diseased or dysfunctional endothelium with a thin donor corneal [....] » Read More
Title : Roth spots serving as a clue to underlying acute myeloid leukemia
P Muralidhar, AIIMS Mangalagiri, India
Acute myeloid leukemia is one of the causes of Roth spots. We report here a female patient in her early thirties, of Asian origin, presenting to our ophthalmology outpatient clinic with complaints of decreased visual acuity in the Right eye along with generalized weakness, palpit [....] » Read More
Title : Navigating the diagnostic maze: A case report of immunoglobulin G4-related disease
Muhammad Ayub Khan, Saidu Group of Teaching Hospital, Pakistan
Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory condition characterized by significant infiltration of immunoglobulin G4 (IgG4)-positive plasma cells within affected tissues, with or without elevated serum IgG4 levels. The prevalence of IgG4-RD re [....] » Read More
Title : Daily artificial tears as a preventive measure for dry eye syndrome in medical students: A systematic review and meta-analysis
Nodira Makhmudova, Akfa Medline University Hospital, Uzbekistan
Purpose: To determine the efficacy of the daily artificial tears usage as a dry eye syndrome prophylaxis among medical students, who are at increased risk due to lifestyle factors. Methods: We performed a systematic review and meta-analysis following the Preferred Reporting Item [....] » Read More
Title : Effect of combination of anti-VEGF and corticosteroid use in two patients with early-onset central retinal vein occlusion
Javokhirbek Ravshanbekov, Akfa Medline University Hospital, Uzbekistan
Purpose: Central Retinal Vein Occlusion (CRVO) is an uncommon condition in young adults that can lead to severe visual impairment if untreated. This study evaluates the treatment outcomes of two young male patients with CRVO who underwent a combination of intravitreal anti-V [....] » Read More
Title : Atopy and its role in the development and progression of keratoconus: a systematic review and meta-analysis
Mokhiryam Aliyeva, Akfa Medline University Hospital, Uzbekistan
Purpose:Progressive condition which is characterized by corneal thinning,distorted astigmatism and impaired vision is called keratoconus (KC). Development of a disease is often associated with genetic predisposition and environmental factors. This study seeks to investigate the r [....] » Read More
Title : Anti-inflammatory properties of omega-3 fatty acids and its clinical significance in the treatment of dry eye syndrome
Jamshid Mamatov, Akfa Medline University Hospital, Uzbekistan
Purpose: to evaluate the effectiveness of nutritional omega-3 fatty acid supplementation in the management of dry eye disease (DED). We focused on the anti-inflammatory properties of omega-3 and its impact on the symptoms and signs of DED, especially in patients with meibom [....] » Read More
Title : Outcomes and complications of anterior capsule tear following phacoemulsification cataract surgery
Zahra Akbari, Kerman University of Medical Sciences, Iran (Islamic Republic of)
Background: We aimed to present the outcomes and complications following phacoemulsification cataract surgery complicated by anterior capsule tears. Methods: This study prospectively included patients who had phacoemulsification cataract surgery with anterior capsule tears. The [....] » Read More
Title : Effects of phacoemulsification, viscosynechiolysis, and trabeculectomy on recent cases with acute primary angle closure
Zahra Akbari, Kerman University of Medical Sciences, Iran (Islamic Republic of)
Purpose: To investigate the differences in the effects of phacoemulsification, viscosynechiolysis, and Trabeculectomy on cases with a recent history of Acute Primary Angle Closure (APAC). Methods: Patients with cataracts, Peripheral Anterior Synechia (PAS), and a history of APAC [....] » Read More
Title : Characteristics of peripheral retinal refraction and its role in children with different refractive states
Yanhua Wang, Shanxi Aier Eye Hospital, China
Objective: Peripheral retinal refraction plays a crucial role in myopia, but the specific mechanism is not clear. We refined the retinal partitions to explore the characteristics of peripheral retinal refraction in emmetropic, low and moderate myopic children aged 6 to 12 years o [....] » Read More
Title : Short-term efficacy of defocus spectacle lenses in controlling myopia in children using multispectral refracion topographer
Yaning Chen, Baoding Aier Eye Hospital, China
Purpose: The aim of this article was to investigate the changes in peripheral retinal defocus in children wearing defocus spectacle lenses and to evaluate its relationship with axial growth. Methods: A total of 200 myopic children aged 8-14 who visited our hospital in [....] » Read More
Title : Role of anterior segment optical coherence tomography in detecting subtle kayser fleischer ring
Asad Hussain, AIIMS, India
Case Description: A 70-year-old female presented to the neurology clinic with complaints of bilateral symmetrical hand tremor since three years and head tremor since six months. The patient had a family history of Wilson disease. She was referred to the ophthalmology clinic to sc [....] » Read More
Title : Clinical efficacy and comparative evaluation of topical caspofungin vs Topical natamycin in fungal keratitis
Vanditaa Agarwal, AIIMS, India
Purpose: To compare the clinical Efficacy of Topical Caspofungin vs Topical Natamycin in Fungal Keratitis. Methods: Randomised Comparative Trial (Pilot study) of 20 eyes of 20 patients with fungal kerat [....] » Read More
Title : Mode of delivery in women at risk of rhegmatogenous retinal detachment: A systematic review
Mariam Salah Muhamed Salah Abdulhafiz, Cairo University, Egypt
Background: Rhegmatogenous retinal detachment (RRD) is essentially a tear in the retina leading to vitreous humor accumulation behind it. Despite lacking guidelines contraindicating vaginal delivery for RRD risk, many doctors may recommend cesarean sections due to reported [....] » Read More
Title : The effectiveness of surgical treatment of terson syndrome
Anna Rusanovskaia , State Budgetary Healthcare Institution , Russian Federation
Terson's syndrome (hemorrhagic oculocerebral syndrome) is a vitreal, preretinal, subgialoid or subretinal hemorrhage associated with acute subarachnoid, intracerebral hemorrhage, or traumatic brain injury. The clinical picture is characterized by a sharp mono or bilateral los [....] » Read More
Title : Surgical treatment of chronic macular hole by hydraulic mobilization of the central parts of the retina
Anna Rusanovskaia , State Budgetary Healthcare Institution , Russian Federation
Objective: to evaluate the safety and effectiveness of the technique of hydraulic mobilization of the central parts of the retina in the surgical treatment of chronic macular ruptures. Materials and methods: 11 patients (11 eyes) with chronic macular rupture were under obse [....] » Read More
Title : Fabrication of chondroitin sulfate functionalized albumin nanoparticles with taurine and necrostatin for targeted glaucoma treatment
Haroon Iqbal, Wenzhou Medical University, China
Glaucoma is the leading cause of irreversible blindness worldwide, characterized by progressive vision loss due to the selective damage to retinal ganglion cells (RGCs) and their axons. Oxidative stress is generally believed as one key factor of RGCs death. Recently, necroptosis [....] » Read More
Title : Evaluation and implementation of a probing model for nasolacrimal duct probing simulation: A pilot study in ophthalmology residents
Saralee Theerakulpisut, Prince of Songkla university, Thailand
Introduction: Congenital nasolacrimal duct obstruction (CNLDO) is a leading cause of epiphora in children, commonly treated through probing. Traditional training methods, which involve hands-on practice with pediatric patients, face limitations due to ethical concerns and limited [....] » Read More
Title : Classification of neovascularization using wide-field OCT-A in PDR
Rajpal Vohra, All India Institute of Medical Sciences, India
Purpose: To classify neovascularization in treatment naïve patients of PDR based on wide-field Optical Coherence Tomography – Angiography (OCT-A) Methods: All patients with PDR underwent detailed ocular examination including optical coherence tomography angiography (Z [....] » Read More
Title : Navigating the complexity of MacTel: A case report
Aakriti Agarwal, Hamdard Institute of Higher Education and Research, India
Aims/ Purpose: To report a patient with bilateral macular telangiectasia Methods: Patient came to the eye OPD with complaints of diminution of vision of both eyes Results: A 50 year old female came to the eye OPD with gradual, painless diminution of vision both eyes. She had no [....] » Read More
Title : An interesting case of CMV anterior uveitis
Meghna Ghodarope, Santosh Medical College and Hospital, India
Cytomegalovirus (CMV) anterior uveitis is the predominant ocular manifestation of CMV in immunocompetent individuals, typically arising from local reactivation of latent CMV and usually presents unilaterally. Characterized by mild anterior chamber inflammation, elevated intraocul [....] » Read More
Title : Case report: Orbital trauma mimicking globe rupture: A case of preserved vision
Piyush Jain, Maharaja Krushna Chandra Gajapati Medical College, India
This case report describes a 38-year-old male who presented with significant orbital trauma following an injury by a wooden object. Despite a concerning CT scan suggesting right globe rupture, surgical exploration revealed an extraconal foreign body with an intact globe. This r [....] » Read More
Title : Retinal injury from accidental laser exposure: A case report
Muhammad Saad Abbas, Aga Khan University, Pakistan
A 31-year-old female dermatologist reported visual disturbances, including haziness and floaters in her left eye, after accidental exposure to a picosecond laser. Initial ophthalmologic evaluation revealed a visual acuity of 20/25 in both eyes, with normal intraocular pressure an [....] » Read More
Title : Protein and mineral malnutrition in military personnel and its association with dry eye syndrome
Jamshid Mamatov, Akfa Medline University Hospital, Uzbekistan
Military personnel are frequently faced with environmental challenges and operational demands.These barriers increase vulnerability to nutrient deficiencies including minerals and proteins imbalance. Such nutrient deprivation can make a disadvantageous impact on ocular wellness,e [....] » Read More
Title : Deep learning convolutional neural network diabetic retinopathy detection using gaussian filter preprocessing
Noor Dalahma, University of Jordan, Jordan
Background: Diabetic Retinopathy (DR) is a severe complication of diabetes that affects retinal blood vessels and can lead to blindness. The Middle East faces a significant public health challenge due to the high prevalence of DR among diabetics, with rates reaching up to 64% in [....] » Read More
Title : A case of waardenburg syndrome type 1 without deafness
Bright Owusu Prempeh, Anglican eye clinic, Ghana
Purpose: Waardenburg Syndrome is a congenital disease characterised by a white forelock with premature greying of the hair, broad nasal root, eyes of different colours due to heterochromia irides, bushy eye brows with synophrys, hypertelorism, depigmented dermal patches and [....] » Read More
Title : Evaluating patient communication in the retinal unit at Moorfields eye hospital: A survey-based study on intravitreal injection therapy
Yasmin Adelekan Kamara, Moorfields, United Kingdom
Background: Intravitreal injection (IVI) therapy used in the management of exudative retinal diseases has expanded significantly following the introduction of anti-vascular endothelial growth factor (anti-VEGF) drugs. With an ageing population in the UK, the numbers of patients r [....] » Read More
Title : An overview of deep-learning enabled microbial keratitis classification
Savini Hewage, Whittington Health NHS Trust, United Kingdom
Infectious keratitis (IK) is the fifth leading cause of blindness globally. Gold-standard diagnostic techniques of microscopy, cultures and sensitivity from corneal scrapes are limited by low sensitivity, invasiveness, and time lag for identifying causative organisms. This revie [....] » Read More