Leber Hereditary Optic Neuropathy (LHON) is a rare, maternally inherited mitochondrial genetic disorder characterized by sudden, painless vision loss, and represents a significant unmet medical need. The pathophysiology of LHON is characterized by the selective loss of .... » Read More
Tim Jackson, King’s College London, United Kingdom
Aim: To investigate the long term, real-world safety and efficacy of Stereotactic Radiotherapy (SRT) for exudative Age-Related Macular Degeneration (AMD). Methods: This randomised, double-masked, sham-controlled clinical trial recruited 411 participants with active, chr.... » Read More
Shakeel Mohammed, Sunshine Coast Hospital & Health Service, Australia
Riboflavin Transporter Deficiency (RTD), also known as Brown-Vialetto-Van Laere syndrome, is a rare autosomal recessive neurodegenerative disorder caused by pathogenic variants in SLC52A2 and SLC52A3, which encode the riboflavin transporters RFVT2 and RFVT3 (5). Ribofla.... » Read More
Background: Circumscribed Choroidal Hemangioma (CCH) is a benign vascular hamartoma of the choroid that may be detected in adulthood when exudation causes subretinal fluid and macular edema. Because it can clinically mimic amelanotic choroidal melanoma and other choroid.... » Read More
Abdullah Shakeel, Princess Alexandra Hospital NHS Trust, United Kingdom
Introduction: Retinopathy of Prematurity (ROP) is a leading cause of preventable childhood blindness, with increasing use of Anti-Vascular Endothelial Growth Factor (anti-VEGF) therapy. However, the high cost of originator biologics limits access in resource-constrained.... » Read More
Age-Related Macular Degeneration (AMD) is a major cause of irreversible vision loss in the elderly population. Its pathogenesis is multifactorial, with inflammation and vascular changes playing significant roles. Understanding the association between systemic inflammato.... » Read More
Title : Lenadogene nolparvovec gene therapy in leber hereditary optic neuropathy
Magali Taiel, GenSight Biologics, France
Leber Hereditary Optic Neuropathy (LHON) is a rare, maternally inherited mitochondrial genetic disorder characterized by sudden, painless vision loss, and represents a significant unmet medical need. The pathophysiology of LHON is characterized by the selective loss of .... » Read More
Title : Stereotactic radiotherapy for wet age-related macular degeneration: year 4 results of a randomised, double-masked, sham-controlled trial
Tim Jackson, King’s College London, United Kingdom
Aim: To investigate the long term, real-world safety and efficacy of Stereotactic Radiotherapy (SRT) for exudative Age-Related Macular Degeneration (AMD). Methods: This randomised, double-masked, sham-controlled clinical trial recruited 411 participants with active, chr.... » Read More
Title : Unique retinal findings in a case of riboflavin transporter deficiency
Shakeel Mohammed, Sunshine Coast Hospital & Health Service, Australia
Riboflavin Transporter Deficiency (RTD), also known as Brown-Vialetto-Van Laere syndrome, is a rare autosomal recessive neurodegenerative disorder caused by pathogenic variants in SLC52A2 and SLC52A3, which encode the riboflavin transporters RFVT2 and RFVT3 (5). Ribofla.... » Read More
Title : Circumscribed choroidal hemangioma presenting with acute metamorphopsia and exudative maculopathy: A case report
Muallah, Shaikh Zayed Hospital, Pakistan
Background: Circumscribed Choroidal Hemangioma (CCH) is a benign vascular hamartoma of the choroid that may be detected in adulthood when exudation causes subretinal fluid and macular edema. Because it can clinically mimic amelanotic choroidal melanoma and other choroid.... » Read More
Title : The safety and efficacy of anti-VEGF biosimilars in retinopathy of prematurity
Abdullah Shakeel, Princess Alexandra Hospital NHS Trust, United Kingdom
Introduction: Retinopathy of Prematurity (ROP) is a leading cause of preventable childhood blindness, with increasing use of Anti-Vascular Endothelial Growth Factor (anti-VEGF) therapy. However, the high cost of originator biologics limits access in resource-constrained.... » Read More
Title : Correlation of choroidal thickness and c-reactive protein levels in patients with age-related macular degeneration
Kritika, Gupta Eye Hospital, India
Age-Related Macular Degeneration (AMD) is a major cause of irreversible vision loss in the elderly population. Its pathogenesis is multifactorial, with inflammation and vascular changes playing significant roles. Understanding the association between systemic inflammato.... » Read More