Leber Hereditary Optic Neuropathy (LHON) is a rare, maternally inherited mitochondrial genetic disorder characterized by sudden, painless vision loss, and represents a significant unmet medical need. The pathophysiology of LHON is characterized by the selective loss of .... » Read More
Tim Jackson, King’s College London, United Kingdom
Aim: To investigate the long term, real-world safety and efficacy of Stereotactic Radiotherapy (SRT) for exudative Age-Related Macular Degeneration (AMD). Methods: This randomised, double-masked, sham-controlled clinical trial recruited 411 participants with active, chr.... » Read More
Shakeel Mohammed, Sunshine Coast Hospital & Health Service, Australia
Riboflavin Transporter Deficiency (RTD), also known as Brown-Vialetto-Van Laere syndrome, is a rare autosomal recessive neurodegenerative disorder caused by pathogenic variants in SLC52A2 and SLC52A3, which encode the riboflavin transporters RFVT2 and RFVT3 (5). Ribofla.... » Read More
Background: Circumscribed Choroidal Hemangioma (CCH) is a benign vascular hamartoma of the choroid that may be detected in adulthood when exudation causes subretinal fluid and macular edema. Because it can clinically mimic amelanotic choroidal melanoma and other choroid.... » Read More
Abdullah Shakeel, Princess Alexandra Hospital NHS Trust, United Kingdom
Introduction: Retinopathy of Prematurity (ROP) is a leading cause of preventable childhood blindness, with increasing use of Anti-Vascular Endothelial Growth Factor (anti-VEGF) therapy. However, the high cost of originator biologics limits access in resource-constrained.... » Read More
Age-Related Macular Degeneration (AMD) is a major cause of irreversible vision loss in the elderly population. Its pathogenesis is multifactorial, with inflammation and vascular changes playing significant roles. Understanding the association between systemic inflammato.... » Read More
Retinal cell death is a common pathological hallmark of several neurodegenerative diseases, including glaucoma, diabetic retinopathy, and age-related macular degeneration. Among these, Primary Open-Angle Glaucoma (POAG) represents the most prevalent form and stands as t.... » Read More
Chaitra MC, Sri Devaraj Urs Medical College, India
Introduction: Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from impaired insulin secretion, insulin action, or both. Among ocular complications, Diabetic Retinopathy is a leading cause of preventable blindness wor.... » Read More
Karishma Parmar, Birmingham Midland Eye Centre, United Kingdom
Case presentation: A young male presented with a two-month history of blurred vision in his right eye. Assessment demonstrated Visual Acuity (VA) of 6/9, markedly reduced colour vision (1/17 Ishihara plates), and a positive relative afferent pupillary defect. Fundus exa.... » Read More
S’ad Shaikh, Princess Alexandra Hospital NHS Trust, United Kingdom
Background: Inherited Retinal Diseases (IRDs) are a clinically and genetically heterogeneous group of conditions causing progressive visual impairment, affecting approximately 5.5 million people worldwide at a prevalence of 1:3, 450. Over 280 causative genes have been i.... » Read More
Aims: To investigate the completion of ophthalmology referral request forms from the Endocrine wards at Good Hope Hospital (GHH). There is no standardised visual acuity assessment equipment available on these wards, therefore it was unlikely that these request forms wer.... » Read More
Shenika Tailor, University Hospitals of Leicester NHS Trust, United Kingdom
Visual impairment is a common but under-recognised complication in children with intracranial tumours, with over half of patients reportedly not receiving timely ophthalmic assessment. Tumours affecting visual pathways—such as optic pathway glioma, craniopharyngioma and.... » Read More
Zhang Liyang, The First Affiliated Hospital of Henan University of Medicine, China
Objective: To examine the association between screen time and dry eye symptoms among medical students, and to test the chain mediating roles of emotional problems and sleep disturbances. Methods: A total of 416 medical students were recruited through convenience samplin.... » Read More
Title : Lenadogene nolparvovec gene therapy in leber hereditary optic neuropathy
Magali Taiel, GenSight Biologics, France
Leber Hereditary Optic Neuropathy (LHON) is a rare, maternally inherited mitochondrial genetic disorder characterized by sudden, painless vision loss, and represents a significant unmet medical need. The pathophysiology of LHON is characterized by the selective loss of .... » Read More
Title : Stereotactic radiotherapy for wet age-related macular degeneration: year 4 results of a randomised, double-masked, sham-controlled trial
Tim Jackson, King’s College London, United Kingdom
Aim: To investigate the long term, real-world safety and efficacy of Stereotactic Radiotherapy (SRT) for exudative Age-Related Macular Degeneration (AMD). Methods: This randomised, double-masked, sham-controlled clinical trial recruited 411 participants with active, chr.... » Read More
Title : Unique retinal findings in a case of riboflavin transporter deficiency
Shakeel Mohammed, Sunshine Coast Hospital & Health Service, Australia
Riboflavin Transporter Deficiency (RTD), also known as Brown-Vialetto-Van Laere syndrome, is a rare autosomal recessive neurodegenerative disorder caused by pathogenic variants in SLC52A2 and SLC52A3, which encode the riboflavin transporters RFVT2 and RFVT3 (5). Ribofla.... » Read More
Title : Circumscribed choroidal hemangioma presenting with acute metamorphopsia and exudative maculopathy: A case report
Muallah, Shaikh Zayed Hospital, Pakistan
Background: Circumscribed Choroidal Hemangioma (CCH) is a benign vascular hamartoma of the choroid that may be detected in adulthood when exudation causes subretinal fluid and macular edema. Because it can clinically mimic amelanotic choroidal melanoma and other choroid.... » Read More
Title : The safety and efficacy of anti-VEGF biosimilars in retinopathy of prematurity
Abdullah Shakeel, Princess Alexandra Hospital NHS Trust, United Kingdom
Introduction: Retinopathy of Prematurity (ROP) is a leading cause of preventable childhood blindness, with increasing use of Anti-Vascular Endothelial Growth Factor (anti-VEGF) therapy. However, the high cost of originator biologics limits access in resource-constrained.... » Read More
Title : Correlation of choroidal thickness and c-reactive protein levels in patients with age-related macular degeneration
Kritika, Gupta Eye Hospital, India
Age-Related Macular Degeneration (AMD) is a major cause of irreversible vision loss in the elderly population. Its pathogenesis is multifactorial, with inflammation and vascular changes playing significant roles. Understanding the association between systemic inflammato.... » Read More
Title : Advanced 3D human-based in vitro models to identify glaucoma-specific molecular markers and to study the pathological crosstalk leading to neuroinflammation
Anna Maria Bassi, University of Genoa, Italy
Retinal cell death is a common pathological hallmark of several neurodegenerative diseases, including glaucoma, diabetic retinopathy, and age-related macular degeneration. Among these, Primary Open-Angle Glaucoma (POAG) represents the most prevalent form and stands as t.... » Read More
Title : A double hit to the macula: Staging hypertension's impact on diabetic macular edema via Optical Coherence Tomography
Chaitra MC, Sri Devaraj Urs Medical College, India
Introduction: Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from impaired insulin secretion, insulin action, or both. Among ocular complications, Diabetic Retinopathy is a leading cause of preventable blindness wor.... » Read More
Title : Atypical central retinal vein occlusion in a young healthy adult
Karishma Parmar, Birmingham Midland Eye Centre, United Kingdom
Case presentation: A young male presented with a two-month history of blurred vision in his right eye. Assessment demonstrated Visual Acuity (VA) of 6/9, markedly reduced colour vision (1/17 Ishihara plates), and a positive relative afferent pupillary defect. Fundus exa.... » Read More
Title : From bench to bedside: Gene therapy for inherited retinal diseases — current evidence, emerging therapies and the global challenge of equitable access
S’ad Shaikh, Princess Alexandra Hospital NHS Trust, United Kingdom
Background: Inherited Retinal Diseases (IRDs) are a clinically and genetically heterogeneous group of conditions causing progressive visual impairment, affecting approximately 5.5 million people worldwide at a prevalence of 1:3, 450. Over 280 causative genes have been i.... » Read More
Title : Compliance of ophthalmology referrals (from endocrine wards) with outlined criteria in request forms
Yasmin Mahamed Cumar Cabdi, University Hospitals Birmingham, United Kingdom
Aims: To investigate the completion of ophthalmology referral request forms from the Endocrine wards at Good Hope Hospital (GHH). There is no standardised visual acuity assessment equipment available on these wards, therefore it was unlikely that these request forms wer.... » Read More
Title : Why a paediatric orthoptic oncology service matters
Shenika Tailor, University Hospitals of Leicester NHS Trust, United Kingdom
Visual impairment is a common but under-recognised complication in children with intracranial tumours, with over half of patients reportedly not receiving timely ophthalmic assessment. Tumours affecting visual pathways—such as optic pathway glioma, craniopharyngioma and.... » Read More
Title : Screen time and dry eye in medical students: A chain mediation mechanism of sleep-emotion
Zhang Liyang, The First Affiliated Hospital of Henan University of Medicine, China
Objective: To examine the association between screen time and dry eye symptoms among medical students, and to test the chain mediating roles of emotional problems and sleep disturbances. Methods: A total of 416 medical students were recruited through convenience samplin.... » Read More