Title : Effect of combination of anti-VEGF and corticosteroid use in two patients with early-onset central retinal vein occlusion
Abstract:
Purpose: Central Retinal Vein Occlusion (CRVO) is an uncommon condition in young adults that can lead to severe visual impairment if untreated. This study evaluates the treatment outcomes of two young male patients with CRVO who underwent a combination of intravitreal anti-VEGF and corticosteroid therapy, demonstrating significant improvements following management.
Methods: Two male patients, aged 35 and 38, presented with sudden vision loss in one eye and were diagnosed with CRVO. Fundoscopic evaluation revealed retinal hemorrhages and macular edema, confirmed by optical coherence tomography (OCT). Both patients were treated with monthly intravitreal injections of anti-VEGF (Aflibercept 0.4 mg) combined with corticosteroid therapy (Triamcinolone). Treatment was administered over six months with regular follow-ups to monitor best-corrected visual acuity (BCVA) and macular thickness.
Results: Both patients showed marked improvements in visual acuity and resolution of macular edema after six months of treatment. OCT findings demonstrated significant reductions in macular thickness, correlating with better structural outcomes. The improvements were more pronounced in the patient with an active lifestyle, who experienced faster recovery compared to the patient with a sedentary lifestyle. Both patients tolerated the treatment well, with no adverse events reported.
Conclusions: The combination of anti-VEGF and corticosteroid therapy is effective in managing CRVO in young adults, leading to substantial improvements in visual function and macular structure. The findings underscore the importance of early intervention and personalized management strategies, taking systemic health and lifestyle factors into consideration.
