Choroideremia

Choroideremia is a rare inherited eye condition predominantly affecting males. It leads to a progressive deterioration of the choroid, retinal pigment epithelium, and retina. Symptoms typically start with night blindness during childhood, progressing to tunnel vision as peripheral vision diminishes in adolescence or early adulthood. By middle age, most individuals with choroideremia experience complete blindness.

The condition stems from mutations in the CHM gene, crucial for normal retinal and choroidal cell function. Currently, there is no cure, and management focuses on symptom alleviation and supportive care. Promising research in gene therapy aims to replace faulty genes with healthy ones, potentially slowing or halting vision loss progression in the future.