Title : Impact of atmosphere in Keratoconjunctivitis Sicca: A Meta-Analysis on different components of air pollutants
Abstract:
Aim: Previous studies assessed the ocular surface integrity and tear stability are climate dependent. Although previous prevalence studies of Keratoconjunctivitis Sicca (KCS) associated with air pollutants were reported from some countries worldwide, there is no uniform conclusion about the influence of different components of air pollutants on cornea in this field. In this study, meta-analysis will be used to summarize the existing papers and get a more objective and comprehensive result.
Methods: A systematic search was finished in MEDLINE, EMBASE, CINAHL, Google Scholar, and the Cochrane Library for relevant articles published from January 01, 1990 to April 29, 2022 without language restrictions. STATA 15.0was used for data analysis and the results included PM2.5, PM10, SO2, NOx, CO, O3were expressed in the form of Odds Radio (OR) and 95% confidence interval (95% CI).
Results: The potential risk factors for KCS were PM2.5(OR=1.048, 95%CI[1.016, 1.081], p=0.003), SO2 (OR=1.034, 95%CI[1.018, 1.051], p<0.001), NOx (OR=1.028, 95%CI[1.018, 1.039], p<0.001), PM10 (OR=1.004, 95%CI[1.003, 1.005], p<0.001)and O3 (OR=1.072, 95%CI[1.045, 1.100], p<0.001), respectively. While CO (OR=1.000, 95%CI [0.995, 1.005], p=0.962) was not associated with KCS.
Conclusions: Meta analysis showed that the potential risk factors for KCS were: PM2.5, SO2, PM10, NOx and O3. While CO was not associated with DED.
