Title : Photoreceptor loss in early type 2 diabetes mellitus related retinopathy is associated with decreased contrast sensitivity a prospective case control study
Abstract:
Purpose: To investigate the changes of Contrast Sensitivity function (CSF) in patients with early diabetic retinopathy and assess the relationship between these alterations and retinal microstructure.
Methods: A total of 90 subject were enrolled. General data from all groups were recorded. CSF was measured by qCSF method. OCT and OCTA were used to analyze retinal microstructure and blood flow. A Pearson correlation analysis investigated the associations between CSF and photoreceptor layer thickness (PRT), cell regularity (CR) levels, and inflammatory markers. The diagnostic value of PRT in identifying visual function impairment in T2DM-related retinopathy was assessed using ROC curve analysis.
Results The AULCSF, middle CS, PRT, CD, CR, and PLR levels decreased progressively with disease severity. GCIPL loss occurred in patients with NPDR. Middle CS was positively correlated with PRT and PLR. PRT differed significantly between patients with T2DM with normal and abnormal CSF. Pearson correlation analysis confirmed a positive association between PRT and middle CS. The AUC for diagnosing abnormal CS based on PRT was 0.921, indicating its clinical significance in detecting CS abnormalities.
Conclusion Early monitoring of PRT and CSF is crucial for the progression of T2DM-related retinopathy.
Key words: T2DM, Diabetic retinopathy; Contrast sensitivity; Photoreceptor.
