Title : New treatment of ptosis and lagophthalmos through regeneration of the nerves or muscles that control the eyelid by activation of quiescent muscle stem cell and neural stem cell with mitochondrial dynamics without surgery
Abstract:
Ptosis is defined as an abnormally low-lying upper eyelid margin on the primary gaze, generally resulting from a congenital or acquired abnormality of the nerves or muscles that control the eyelid. The unilateral or bilateral drooping of the upper eyelid that characterises ptosis can affect appearance and impair visual function, Lagophthalmos describes the incomplete or abnormal closure of the eyelids. Patients who are unable to blink and completely close their eyes are at risk of corneal exposure, evaporation of the tear film, and subsequent exposure keratopathy. This can progress to corneal ulceration and perforation. Paralytic lagophthalmos is defined as incomplete closure of the eyelids as a result of paralysis of the seventh cranial nerve. Skeletal muscle and peripheral nerves( including facial nerve) have a remarkable regenerative capacity, mainly due to thr spare pool of satellite cells(muscle stem cell) and neural stem cells. This review showed that ptosis & lagophthalmos are dramatically improved through regeneration of satellite cells and peripheral neural stem cells by activation of quiescent muscle stem cell & neural stem cell with increasing mitochondrial ATP without surgery. Periodic treatment is required according to the severity of the disease.
