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3rd Edition of

International Ophthalmology Conference

March 10-12, 2025 | Rome, Italy

IOC 2025

Navigating the diagnostic maze: A case report of immunoglobulin G4- related disease

Speaker at International Ophthalmology Conference 2025 - Muhammad Ayub Khan
Saidu Group of Teaching Hospital, Pakistan
Title : Navigating the diagnostic maze: A case report of immunoglobulin G4- related disease

Abstract:

Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory condition characterized by significant infiltration of immunoglobulin G4 (IgG4)-positive plasma cells within affected tissues, with or without elevated serum IgG4 levels. The prevalence of IgG4-RD remains largely undetermined due to diagnostic challenges, as the condition is frequently unrecognized or misdiagnosed. This report describes the case of a 63-year-old man who was ultimately diagnosed with this rare condition after an extensive two-year period of elusive symptoms. Initially presenting with intermittent body pains and fluctuating fever, his condition progressively evolved to include severe right orbital swelling with marked tenderness and ecchymosis, recurrent non-tender nodules on his arm, and diminished vision. A detailed review of his medical history prompted the consideration of IgG4-RD, leading to the measurement of serum human IgG4 levels, which were found to be significantly elevated at 1504 mg/L (normal range: 39.2-864 mg/L). Following his diagnosis, treatment with glucocorticoids (0.6 mg/kg for one month) was initiated, resulting in a positive clinical response. This case emphasizes the critical importance of considering less common conditions in the differential diagnosis of patients presenting with complex, multi-system symptoms.

Biography:

Dr. Muhammad Ayub Khan is an Associate Professor of Medicine with a focus on Chronic diseases and rare presentation of rare diseases at SAIDU GROUP OF TEACHING HOSPITAL. With extensive experience in both clinical practice and research, Dr. Muhammad Ayub Khan has contributed to numerous peer-reviewed publications and presented at national and international conferences. Their research interests include Case reports, meta-analysis, and systemic review, and they are dedicated to advancing patient care through innovation and education. Dr. Muhammad Ayub Khan is passionate about mentoring the next generation of healthcare professionals.

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