Title : Characteristics of peripheral retinal refraction and its role in children with different refractive states
Abstract:
Objective: Peripheral retinal refraction plays a crucial role in myopia, but the specific mechanism is not clear. We refined the retinal partitions to explore the characteristics of peripheral retinal refraction in emmetropic, low and moderate myopic children aged 6 to 12 years old, and investigate its role in the occurrence and development of myopia.
Methods: A total of 814 subjects (814 eyes) who were admitted to the Pediatric Ophthalmology Depokpere emmetropia group (E, ≤+0.50D and ≥-0.50D), low myopia group (LM, ?-0.50D and ≥-3.00D) and moderate myopia group (MM, ?-3.00D and ≥-6.00D). Multispectral refractive topography (MRT) was used to measure the retinal absolute and relative refractive difference value (RDV) in different regions. The range was divided into several areas extending outward from the macular fovea (RDV15, RDV30, RDV45, RDV30-15, RDV45-30 and RDV-45), and Superior, Inferior, Temporal, Nasal RDV (SRDV, IRDV, TRDV, NRDV).
Results: The absolute value of RDV decreased with increasing degree of myopia in all regions (P<0.01). Subjects with different refractive degrees had different relative value of RDV. In nasal position within 45°and temporal position within 30°, the peripheral retina exhibited significantly different relative hyperopic refractive status among Group E, Group LM and Group MM (P<0.05). Spearman correlation analysis showed that SER was negatively correlated with nasal RDV within 30°(especially in the range of NRDV30-15) (r=-0.141, P<0.01), positively correlated with temporal RDV within 15° (r=0.080, P=0.023), and not significantly correlated with SRDV and IRDV when the retina was divided into four parts. AL was positively correlated with nasal RDV within 30°(especially in the range of NRDV30-15) (r=0.109, P=0.002), negatively correlated with temporal RDV within 15° (r=-0.095, P=0.007).
Conclusions: In the development of myopia, the peripheral defocus has significant implications for the genesis of myopia in children. There may be an imbalance between vertical and horizontal eye development. The peripheral defocus of the horizontal direction, especially within the range of NRDV30, has a greater effect on the development of myopia in children.
Keywords: Myopia, Peripheral retinal refraction, Relative difference value, Multispectral refractive topography, Children
