PANIS method (Plasma Assisted NonInvasive Surgery) is about treatment of more than 15 ocular surface diseases with just one device using plasma technology. But the difference between PANIS and past modalities which attracts ophthalmologists all over the world is that, this novel approach is safe, cheap, office-based and without operation room, easy for patient and doctor as well, with fast learning curve and also fast time of procedure, substitution for suture and glue in some eye operations and last but not least it has not any side effect or pain during procedure. This device is so ergonomic for surgeon's hand and it has a needle that should be at a special distance like 1 millimeter with target tissue so that it could ionizes the air between needle and tissue named plasma. Plasma can sublimate very very thin layer of tissue and in our animal phase of study our team proved that it can't pass epithelial cells and also this sublimation footprint can heal in just 2 or 3 days. Before ophthalmology usage of this plasma technology, dermatologists and some ophthalmologists used it for patients who need blepharoplasty surgery but they are contraindication for surgery for any possible reason. They applied plasma spots on eyelid skin and sublimate it so eyelid will stretch and eyelid ptosis will treat. Since 2016, Dr Nejat applied plasma spots on conjunctiva tissue of eye for the first time and of course his team evaluated the safety of this method for eye before human phase on rabbit and rat. Our team 14 articles about treating ocular surface diseases with PANIS method and we are working on many different and novel projects using plasma in ophthalmology which will be publish soon.