3rd Edition of

International Ophthalmology Conference

March 20-22, 2025 | Madrid, Spain

IOC 2022

Yongzhe Gu

Speaker at International  Ophthalmology Conference 2022 - Yongzhe Gu
Tongji University, China
Title : Fundus changes evaluated by OCTA in patients with cerebral small vessel disease and their correlations: A Cross-Sectional study

Abstract:

Objective: To detect fundus changes in patients with cerebral small vessel disease (CSVD) using optical coherence tomography angiography (OCTA) and to investigate the correlations between CSVD and fundus changes. Methods: From January 2019 to January 2020, patients diagnosed with CSVD by magnetic resonance imaging (MRI) were enrolled in our study and received fundus examinations using OCTA. CSVD was defined as white matter hyperintensities, enlarged perivascular spaces, lacunes, or microbleeds on MRI. OCTA parameters included foveal avascular zone areas, retinal nerve fibre layer thickness, and capillary densities of the superficial retinal capillary plexuses, deep retinal capillary plexuses, and the radial peripapillary capillary network of the disc. Univariate and multivariate logistic regression analyses were performed to explore the correlation between CSVD and fundus changes. Results: A total of 115 patients (40% male) were enrolled and analysed, and the mean age was 65.11 ± 11.23 years. After multivariate logistic regression analysis, the radial peripapillary capillary network density was negatively correlated with severity of deep white matter lesions (OR: 0.909; 95% CI: 0.828–0.998; P = 0.046) and perivascular spaces (OR: 0.881; 95% CI: 0.779–0.995; P = 0.041). Parafoveal vessel densities of the superficial retinal capillary plexuses were independently correlated with lacunes (OR: 0.889; 95% CI: 0.817–0.967; P = 0.006). Conclusion: OCTA parameters were correlated with CSVD, indicating that OCTA is a potential method for CSVD screening.

 

Biography:

Dr. Gu studied Clinical Medicine at Wenzhou Medical University and graduated as BM. She then studied Neurology at Tongji University as PhD. She now is a member of the research group of Prof. Xueyuan Liu at the Department of Neurology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China.

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